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Perceptual Analysis of Speech in Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP)
Lena Hartelius & Björn Holmberg

Dysarthria is a frequent and early-appearing manifestation of the two most common Parkinson plus syndromes Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP). In both conditions, dysarthria is usually described as mixed, with a combination of hypokinetic, spastic and ataxic features. In the present study, speech samples of twenty-seven patients diagnosed with MSA or PSP were assessed by a group of experienced clinicians using an assessment protocol including 29 speech dimensions. Perceptual characteristics were found to differ, and seven dimensions reliably distinguished the two groups. The patients with PSP had shorter disease duration, but were significantly more neurologically disabled as well as significantly more affected by signs of dysarthria.

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